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The use of disease-modifying agents may reduce the requirement for NSAIDs. The use of such agents does not mean that intervention in the basic pathogenetic mechanisms (albeit hoped for) is achievable. Rather, disease-modifying therapy permits acutely acting agents to be used as add-ons or as required.
Therapeutic uses. Because of their narrow therapeutic margin, these antiarrhythmics are only employed when rhythm disturbances are of such severity as to impair the pumping action of the heart, or when there is a threat of other complications. The choice of drug is empirical. If the desired effect is not achieved, another drug is tried. Combinations of antiarrhythmics are not customary. |
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