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Thus, cholesterol-containing stones can be dissolved slowly. This effect can be achieved by long-term oral administration of chenodeoxycholic acid (CDCA) or ursodeoxycholic acid (UDCA). Both are physiologically occurring, stereoisomeric bile acids (position of the 7-hydroxy group being ? in UCDA and ? in CDCA).
Finally, nifedipine may be useful in chronic stable, or in variant angina (5–20 mg, capsule to be bitten and the contents swallowed). For sustained daytime angina prophylaxis, nitrates are of limited value because “nitrate pauses” of about 12 h are appropriate if nitrate tolerance is to be avoided.

 

This approach is based on the expectation that binding sites will retain their characteristic properties during cell homogenization. Provided that binding sites are freely accessible in the medium in which membrane fragments are suspended, drug concentration at the “site of action” would equal that in the medium.
A detectable immune response, the allergic reaction, occurs. This can be of severe intensity, even at a low dose of the antigen. Four types of reactions can be distinguished: Type 1, anaphylactic reaction. Drug-specific antibodies of the IgE type combine via their Fc moiety with receptors on the surface of mast cells.

 

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